Glomerular Filtration Rate calculation based on the Royal Free Hospital cirrhosis GFR

This calculator is based on the publication by Kalafateli et al. (Hepatology 2017; 65:582-91). It is only intended for patients with established cirrhosis. Please note that it is not validated in patients of African or Afro-American origin.

Calculator
Information

Please, cite this work as:

Kalafateli, M., Wickham, F., Burniston, M., Cholongitas, E., Theocharidou, E., Garcovich, M., O'Beirne, J., Westbrook, R., Leandro, G., Burroughs, A. K. and Tsochatzis, E. A. (2017), Development and validation of a mathematical equation to estimate glomerular filtration rate in cirrhosis: The Royal Free Hospital cirrhosis glomerular filtration rate. Hepatology, 65: 582–591. doi:10.1002/hep.28891

The formula is as follows:

$$ \begin{eqnarray} \textrm{GFR} \, \left[\frac{\textrm{m}L}{\textrm{min}\,1.73\,m^{2}}\right] & = & 45.9 \times \left( \textrm{creatinine}^{-0.836} \left[\frac{\mu \textrm{mol}}{L}\right]\right) \\ && \times \left( \textrm{urea}^{-0.229} \left[\frac{\textrm{mmol}}{L}\right]\right) \times \textrm{INR}^{-0.113} \\ && \times \left( \textrm{age}^{-0.129} \left[ \textrm{years} \right] \right) \times \left( \textrm{sodium}^{0.972} \left[ \frac{\textrm{mmol}}{L} \right] \right) \\ && \times 1.236 \, (\textrm{if male}) \\ && \times 0.92 \, \left( \textrm{if} \, \frac{\textrm{moderate}}{\textrm{severe}} \, \textrm{ascites} \right) \ \end{eqnarray} $$

Units

Gender

Female Male

Age

years

Ascites

Moderate or Severe Yes

Creatinine

Urea

Sodium

mmol/l

INR

...

Disclaimer: All information is provided for educational purposes only. THIS INFORMATION IS NOT INTENDED TO REPLACE CLINICAL JUDGMENT OR GUIDE INDIVIDUAL PATIENT CARE IN ANY MANNER.

Developed with ♥ by the UCL's Research Software Development Group.
Generously funded by the Royal Free Charity.